ER L1 Examples
Contents |
PCR
This example presents the different relations between the four entities involved in a Polymerase Chain Reaction (PCR). This examplifies the use of the entity, the logical operator or, the state variable existence, the unit of information, as well as the relationships interaction, assignment, necessary stimulation and absolute inhibition.
CaMKII in synaptic plasticity
This example depicts the effect of a depolarisation (dV) on the intracellular calcium, that binds to calmodulin, that itself binds to the calcium/calmoduline kinase II (CaMKII). The binding of calmodulin inhibits the folding of CaMKII monomer on itself, thus relieving the inhibition on the kinase activity. The phosphorylation of the glutamate receptors finally leads to the Long Term Potentiation (LTP) of the synapses. In addition, the map shows the effect of trans-phosphorylation on threonine 286, that makes the enzyme constitutively active, and on threonine 306, that renders the kinase insensitive to calmodulin, as well as the dimerisation of the kinase. In blue are the relationships enhancing the synaptic weight and in red the relationships decreasing it.
Repressilator
The repressilator is a circular system of three genes which products sequentially inhibit the expression of the next gene. Both the model and its in vitro realization were published by Michael Elowitz and Stanislas Leibler in 2000, in a publication that is seen as one of the milestones in the birth of Synthetic Biology.
Development of Diabetic Retinopathy
The following map was presented to the annual SBGN competition 2010, section best map.
[ full size map ]
